FTI-277 (hydrochloride)
FTI-277 (hydrochloride)
CAS: 180977-34-8
Molecular Formula: C22H30ClN3O3S2
FTI-277 (hydrochloride) - Names and Identifiers
| Name | FTI-277 (hydrochloride) |
| Synonyms | FTI 277 CS-1757 FTI 277 HCl FTI 277 HCL FTI 277 HYDROCHLORIDE FTI-277 (hydrochloride) FTI-277 TRIFLUOROACETATE SALT 4-[2(R)-amino-3-mercaptopropyl]amino-2-phenylbenzoyl-(S)-methionine methyl ester hydrochloride (S)-methyl 2-(5-(((R)-2-amino-3-mercaptopropyl)amino)-[1,1'-biphenyl]-2-ylcarboxamido)-4-(methylthio)butanoate FTI 277 HCl |
| CAS | 180977-34-8 |
| EINECS | 604-604-1 |
FTI-277 (hydrochloride) - Physico-chemical Properties
| Molecular Formula | C22H30ClN3O3S2 |
| Molar Mass | 484.075 |
| Solubility | DMSO: ≥ 4.7 mg/mL |
| Appearance | amorphous semi-solid |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | FTI-277 inhibits Ras processing with an IC50 of 100 nM, but not the geranylgeranylated Rap1A processing in whole cells. FTI-277 induces accumulation of cytoplasmic non-farnesylated H-Ras, accumulates inactive Ras/Raf complexes in the cytoplasm and blocks constitutive MAPK activation in H-RasF cells. FTI-277 causes increased apoptosis after irradiation and increases radiosensitivity in H-ras-transformed rat embryo cells. FTI-277 also inhibits cell growth and induces apoptosis in drug-resistant myeloma tumor cells. In SH-SY5Y cells, FTI-277 diages the toxic effects of methomorphetamine on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation. FTI-277 inhibited Ras processing with an IC50 of 100 nM, but did not inhibit tetra-isoprenated Rap1A processing in whole cells. FTI-277 induces accumulation of cytoplasmic farnesylation H-Ras, accumulation of inactive Ras/Raf in the cytoplasm, and blocking constitutive MAPK activation in H-RasF cells. FTI-277 causes an increase in apoptosis after radiation and increases the radiosensitivity of H-ras transformed rat embryonic cells. In drug-resistant myeloma cells, FTI-277 also inhibit cell growth and induce apoptosis. In SH-SY5 cells, FTI-277 reduced cell degeneration, activation, c-Jun-N-terminal kinase cascade and methamphetamine-induced toxic effects during Ras activation. |
| In vivo study | In mice coinfected with hepatitis B virus (HBV) and HDV, FTI-277 (50 mg/kg/d I. p.) effective clears HDV viremia. in mice infected with hepatitis B Virus (HBV) and HDV, FTI-277 (50 mg/kg/d I. p.) HDV Virus was effectively cleared. |
FTI-277 (hydrochloride) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
FTI-277 (hydrochloride) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.066 ml | 10.329 ml | 20.658 ml |
| 5 mM | 0.413 ml | 2.066 ml | 4.132 ml |
| 10 mM | 0.207 ml | 1.033 ml | 2.066 ml |
| 5 mM | 0.041 ml | 0.207 ml | 0.413 ml |
Last Update：2024-01-02 23:10:35
FTI-277 (hydrochloride) - Introduction
FTI-277 (hydrochloride) is a compound whose chemical formula is C26H26FN3O2S · HCl. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: FTI-277 (hydrochloride) is a white solid.
-Solubility: It is soluble in water and some organic solvents.
-Melting point: According to literature reports, the melting point of this compound is about 191-193°C.
Use:
-Anti-tumor activity: FTI-277 (hydrochloride) belongs to a class of compounds called glutaryl isoxazole (thiazolodiazepine), which has anti-tumor activity. It prevents the growth and spread of tumor cells by inhibiting the activity of a class of enzymes called acyl transferases (ftases).
Preparation Method:
- FTI-277 (hydrochloride) can be synthesized by synthetic routes reported in the literature. The synthesis process is complex, usually involving multiple steps of chemical reaction and purification process.
Safety Information:
- FTI-277 (hydrochloride) is a chemical compound used in laboratory research and may pose a risk to humans and the environment.
-Relevant laboratory safety procedures need to be followed when using and handling the compound.
-For researchers using this compound, appropriate personal protective equipment should be used, such as laboratory gloves and protective glasses.
-It should be stored in a dry, low temperature and well-ventilated place, avoiding contact with oxidants and flammable materials.
Please pay attention to safety when using this compound in the laboratory and strictly abide by relevant regulations.
Nature:
-Appearance: FTI-277 (hydrochloride) is a white solid.
-Solubility: It is soluble in water and some organic solvents.
-Melting point: According to literature reports, the melting point of this compound is about 191-193°C.
Use:
-Anti-tumor activity: FTI-277 (hydrochloride) belongs to a class of compounds called glutaryl isoxazole (thiazolodiazepine), which has anti-tumor activity. It prevents the growth and spread of tumor cells by inhibiting the activity of a class of enzymes called acyl transferases (ftases).
Preparation Method:
- FTI-277 (hydrochloride) can be synthesized by synthetic routes reported in the literature. The synthesis process is complex, usually involving multiple steps of chemical reaction and purification process.
Safety Information:
- FTI-277 (hydrochloride) is a chemical compound used in laboratory research and may pose a risk to humans and the environment.
-Relevant laboratory safety procedures need to be followed when using and handling the compound.
-For researchers using this compound, appropriate personal protective equipment should be used, such as laboratory gloves and protective glasses.
-It should be stored in a dry, low temperature and well-ventilated place, avoiding contact with oxidants and flammable materials.
Please pay attention to safety when using this compound in the laboratory and strictly abide by relevant regulations.
Last Update：2024-04-10 22:29:15
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CAS: 180977-34-8
Tel: 18301782025
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QQ: 3008007409
Spot supply
Product Name: FTI-277 Visit Supplier Webpage Request for quotationCAS: 180977-34-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: FTI-277 (hydrochloride) Visit Supplier Webpage Request for quotationCAS: 180977-34-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: FTI 277 HCl Visit Supplier Webpage Request for quotationCAS: 180977-34-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: FTI-277 (hydrochloride) Visit Supplier Webpage Request for quotation
CAS: 180977-34-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 180977-34-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
FTI-277 (hydrochloride)
1-二乙氨基-4-氨基戊烷
N-乙酰-DL-Α-丙氨酸
2-氯噁唑-4-羧酸乙酯
3-Heptyllevulinic acid methyl ester
6,6-二甲基-1-氯-2-烯-4-庚炔(顺反异构体混合物)
三苯甲基四(五氟苯基)硼酸盐
ALPHA-PHENYLHYDRACRYLIC ACID
p-Aminobenzoic acid
克林沙星盐酸盐溶液, 100PPM
1-二乙氨基-4-氨基戊烷
N-乙酰-DL-Α-丙氨酸
2-氯噁唑-4-羧酸乙酯
3-Heptyllevulinic acid methyl ester
6,6-二甲基-1-氯-2-烯-4-庚炔(顺反异构体混合物)
三苯甲基四(五氟苯基)硼酸盐
ALPHA-PHENYLHYDRACRYLIC ACID
p-Aminobenzoic acid
克林沙星盐酸盐溶液, 100PPM